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Total 63313 results found since Jan 2013.

Lymphatic compensation during the postoperative period after breast cancer treatment with axillary dissection
The objective of this literature review was to study lymphatic compensation after surgery for breast cancer and the factors that influence this process, with a view to understanding the etiopathogenesis of lymphedema. Articles indexed on Pubmed published from 1985 to 2012 were reviewed. According to the literature, lymphangiogenesis reduces damage to lymph vessels; there is little evidence that Vascular Endothelial Growth Factor is elevated in women with lymphedema; lymphovenous communications can be observed 60 days after surgery; women without lymphedema have acquired alternative mechanisms for removal of proteins from t...
Source: Jornal Vascular Brasileiro - August 26, 2015 Category: Surgery Source Type: research

Effects Of Exercise On Vascular Toxicity Associated With Breast Cancer Treatment: A Narrative Review
Curr Vasc Pharmacol. 2022 Dec 28. doi: 10.2174/1570161121666221228141150. Online ahead of print.ABSTRACTBreast cancer is the most common cancer among women worldwide, and its incidence is linearly associated with age. The development of cancer treatments has changed the prognosis of this disease. Despite effective treatments, cardiovascular complications in middle-aged and older women have become challenging. Physical exercise is a powerful tool to prevent senescence symptoms and diseases, besides being an essential component for cardiovascular diseases and cancer prevention and treatment. The present narrative review cons...
Source: Current Vascular Pharmacology - December 29, 2022 Category: Drugs & Pharmacology Authors: Marina L D Pera Guilherme F Speretta Source Type: research

PICC-PORT totally implantable vascular access device in breast cancer patients undergoing chemotherapy.
CONCLUSION: The peripherally inserted central catheter-PORT is a safe vascular device for chemotherapy delivery that achieves similar clinical results as traditional long-term vascular access devices (peripherally inserted central catheter and arm totally implantable vascular access device, in particular) in breast cancer patients. PMID: 31674857 [PubMed - as supplied by publisher]
Source: The Journal of Vascular Access - November 2, 2019 Category: Surgery Tags: J Vasc Access Source Type: research

Metastatic breast carcinoma induces vascular endothelial dysfunction in Balb-c mice: Role of the tumor necrosis factor-α and NADPH oxidase.
In this study, highly metastatic breast carcinoma cells which was derived from liver or brain metastasis of 4T1 murine breast carcinoma (4TLM and 4TBM, respectively), and 67NR cells which is tumorogenic but non-metastatic cells were used. Female Balb-c mice 8-10weeks old were divided into following groups: (1) Control, (2) injected with 67NR, (3) injected with 4TLM, and (4) injected with 4TBM orthotopically. Thoracic aorta was removed 23-25days after injection of tumor cells. Isometric tension studies were performed in response to potassium chloride (KCl), phenylephrine (Phe), acetylcholine (ACh, an endothelium-dependent v...
Source: Vascular Pharmacology - August 7, 2013 Category: Drugs & Pharmacology Authors: Dalaklioglu S, Tasatargil A, Kale S, Gamzetanriover, Dilmac S, Erin N Tags: Vascul Pharmacol Source Type: research

Transcriptional repression of VEGF by ZNF24: mechanistic studies and vascular consequences in vivo
VEGF is a key regulator of normal and pathologic angiogenesis. Although many trans-activating factors of VEGF have been described, the transcriptional repression of VEGF remains much less understood. We have previously reported the identification of a SCAN domain–containing C2H2 zinc finger protein, ZNF24, that represses the transcription of VEGF. In the present study, we identify the mechanism by which ZNF24 represses VEGF transcription. Using reporter gene and electrophoretic mobility shift assays, we identify an 11-bp fragment of the proximal VEGF promoter as the ZNF24-binding site that is essential for ZNF24-medi...
Source: Blood - January 24, 2013 Category: Hematology Authors: Jia, D., Hasso, S. M., Chan, J., Filingeri, D., D'Amore, P. A., Rice, L., Pampo, C., Siemann, D. W., Zurakowski, D., Rodig, S. J., Moses, M. A. Tags: Vascular Biology Source Type: research

Vascular endothelial growth factor polymorphisms and clinical outcome in patients with metastatic breast cancer treated with weekly docetaxel
ectasides & G Fountzilas
Source: The Pharmacogenomics Journal - September 24, 2013 Category: Drugs & Pharmacology Authors: A K KoutrasV KotoulaC PapadimitriouD DionysopoulosF ZagouriH P KalofonosH P KoureaD V SkarlosE SamantasK PapadopoulouP KosmidisD PectasidesG Fountzilas Tags: breast cancer clinical outcome polymorphisms vascular endothelial growth factor weekly docetaxel Source Type: research

Inorganic polyphosphate elicits proinflammatory responses through activation of mTOR complexes 1 and 2 in vascular endothelial cells
ConclusionsPolyP, through interaction with RAGE and P2Y1, activates both mTORC1 and mTORC2 signaling network. Both proinflammatory and mTOR signaling functions of polyP are linked.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - March 16, 2015 Category: Hematology Authors: Seyed Mahdi Hassanian, Peyman Dinarvand, Stephanie A. Smith, Alireza R. Rezaie Tags: Original Article ‐ Vascular Biology Source Type: research

Cadherin-5: a biomarker for metastatic breast cancer with optimum efficacy in oestrogen receptor-positive breast cancers with vascular invasion
iam V Dwek
Source: British Journal of Cancer - April 25, 2016 Category: Cancer & Oncology Authors: Simon A FryClaire E RobertsonRuth SwannMiriam V Dwek Tags: breast cancer metastasis biomarker glycosylation cadherin-5 ER positive vascular invasion Source Type: research